CASP2 polyclonal antibody
产品名称： CASP2 polyclonal antibody
英文名称： CASP2 polyclonal antibody
产品编号： PAB9823
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CASP2.
- Immunogen:
- A synthetic peptide corresponding to N-terminus of human CASP2.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Caspase-2 function in response to DNA damage.
Zhivotovsky B, Orrenius S.Biochem Biophys Res Commun. 2005 Jun 10;331(3):859-67.
- 2.
- Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
Martinon F, Tschopp J.Cell. 2004 May 28;117(5):561-74.
- 3.
- Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.
Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS, Flavell RA.Science. 1995 Mar 31;267(5206):2000-3.
- Entrez GeneID:
- 835
- Gene Name:
- CASP2
- Gene Alias:
- CASP-2,ICH-1L,ICH-1L/1S,ICH1,NEDD2
- Gene Description:
- caspase 2, apoptosis-related cysteine peptidase
- Omim ID:
- 600639
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The proteolytic cleavage of this protein is induced by a variety of apoptotic stimuli. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq
- Other Designations:
- ICH-1 protease,NEDD2 apoptosis regulatory,caspase 2,neural precursor cell expressed, developmentally down-regulated 2
- Related Disease
- Adenocarcinoma
- Esophageal Neoplasms
- Gastrointestinal Stromal Tumors
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Hematologic Diseases
- Hodgkin Disease
- Lymphoma, Non-Hodgkin
- Lymphoproliferative Disorders
- Multiple Sclerosis
- Neoplasm Recurrence, Local
- Neoplasms, Second Primary
- Occupational Diseases
- Prostatic Neoplasms
- Waldenstrom Macroglobulinemia
- Werner syndrome