PRKCA Peptide
产品名称: PRKCA Peptide
英文名称: PRKCA Peptide
产品编号: P2440
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PRKCA.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to residues surrounding T637 of human PRKCA.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Activation of bone morphogenetic protein signaling by a Gemini vitamin D3 analogue is mediated by Ras/protein kinase C alpha.
Lee HJ, Ji Y, Paul S, Maehr H, Uskokovic M, Suh N.Cancer Res. 2007 Dec 15;67(24):11840-7.
- 2.
- Protein kinase C-dependent control of Bcl-x alternative splicing.
Revil T, Toutant J, Shkreta L, Garneau D, Cloutier P, Chabot B.Mol Cell Biol. 2007 Dec;27(24):8431-41. Epub 2007 Oct 8.
- 3.
- Hog barn dust slows airway epithelial cell migration in vitro through a PKCalpha-dependent mechanism.
Slager RE, Allen-Gipson DS, Sammut A, Heires A, DeVasure J, Von Essen S, Romberger DJ, Wyatt TA.Am J Physiol Lung Cell Mol Physiol. 2007 Dec;293(6):L1469-74. Epub 2007 Oct 12.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of PRKCA polyclonal antibody (Cat # PAB2834) in Jurkat cell line lysates (35 ug/lane). PRKCA (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human breast carcinoma reacted with PRKCA polyclonal antibody (Cat # PAB2834) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 5578
- Protein Accession#:
- NP_002728;P17252
- Gene Name:
- PRKCA
- Gene Alias:
- AAG6,MGC129900,MGC129901,PKC-alpha,PKCA,PRKACA
- Gene Description:
- protein kinase C, alpha
- Omim ID:
- 176960
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq
- Other Designations:
- aging-associated gene 6,protein kinase C alpha type
- Gene Pathway
- Calcium signaling pathway
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- Gap junction
- Glioma
- GnRH signaling pathway
- Leukocyte transendothelial migration
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Natural killer cell mediated cytotoxicity
- Non-small cell lung cancer
- Pathogenic Escherichia coli infection - EHEC
- Pathways in cancer
- Phosphatidylinositol signaling system
- Tight junction
- Vascular smooth muscle contraction
- VEGF signaling pathway
- Vibrio cholerae infection
- Wnt signaling pathway